The Molecular Basis of Host Pathogen Interactions

Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks

KH Ling, CA Hewitt, KL Tan, PS Cheah, S Vidyadaran, MI Lai, HC Lee, K Simpson, L Hyde, MA Pritchard, GK Smyth, T Thomas, HS Scott

2014-07-22

Background: The Ts1Cje mouse model of Down syndrome (DS) has partial triplication of mouse chromosome 16 (MMU16), which is partial..

Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome

KL Tan, KH Ling, CA Hewitt, PS Cheah, K Simpson, L Gordon, MA Pritchard, GK Smyth, T Thomas, HS Scott

2014-01-01

The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromo..

Spatiotemporal regulation of multiple overlapping sense and novel natural antisense transcripts at the nrgn and camk2n1 gene loci during mouse cerebral corticogenesis

KH Ling, CA Hewitt, T Beissbarth, L Hyde, PS Cheah, GK Smyth, SS Tan, CN Hahn, T Thomas, PQ Thomas, HS Scott

2011-03-01

Nrgn and Camk2n1 are highly expressed in the brain and play an important role in synaptic long-term potentiation via regulation of..

SAGE analysis of genes differentially expressed in presymptomatic TgSOD1G93A transgenic mice identified cellular processes involved in early stage of ALS pathology

M Guipponi, QX Li, L Hyde, T Beissbarth, GK Smyth, CL Masters, HS Scott

2010-05-01

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition in which motor neurons of the spinal cord and motor cor..

Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling

KH Ling, CA Hewitt, T Beissbarth, L Hyde, K Banerjee, PS Cheah, PZ Cannon, CN Hahn, PQ Thomas, GK Smyth, SS Tan, T Thomas, HS Scott

2009-10-02

Background: Development of the cerebral cortex requires highly specific spatio-temporal regulation of gene expression. It is propo..

IP-10-Mediated T cell homing promotes cerebral inflammation over splenic Immunity to Malaria infection

CQ Nie, NJ Bernard, MU Norman, FH Amante, RJ Lundie, BS Crabb, WR Heath, CR Engwerda, MJ Hickey, L Schofield, DS Hansen

2009-04-01

Plasmodium falciparum malaria causes 660 million clinical cases with over 2 million deaths each year. Acquired host immunity limit..